Faculty Title:
Professor of Medicine, Director, Bone Biology Research

Office Location:
Osteoporosis Clinic
Medical Arts & Research Building, 3rd floor
UConn Health Center
263 Farmington Avenue
Farmington, CT 06030-6232
Phone: 860-679-2160

Specialties:
Endocrinology, Osteoporosis

Board Certifications:
American Board of Internal Medicine
American Board of Internal Medicine: Endocrinology and Metabolism

Brief Biosketch: 
Dr Lorenzo is board certified in Internal Medicine and Endocrinology.  He received his M.D. from the State University of New York, Downstate Medical Center.  His residency in Internal Medicine was at the University of Illinois Medical Center, Chicago and his fellowship in Endocrinology was at the University of Connecticut Health Center.  He has been a member of the faculty at the University of Connecticut Health Center since 1979.  His current research interest is the effects of the immune system on the development and function of the osteoclasts, which are the principal bone resorbing cells, and the mechanisms by which estrogen mediates this interaction. 

Selected Publications:
Lee SK, Gardner AE, Kalinowski JF, Jastrzebski SL, Lorenzo JA., RANKL-stimulated osteoclast-like cell formation  in vitro is partially dependent on endogenous interleukin-1 production. Bone 2006 May;38(5):678-85.

Delahunty KM, Shultz KL, Gronowicz GA, Koczon-Jaremko B, Adamo ML, Horton LG, Lorenzo J, Donahue LR, Ackert-Bicknell C, Kream BE, Beamer WG, Rosen CJ. Congenic mice provide in vivo evidence for a genetic locus that modulates serum insulin-like growth factor-I and bone acquisition. Endocrinology. 2006 Aug;147(8):3915-23.

Lee SK, Kalinowski JF, Jacquin C, Adams DJ, Gronowicz G, Lorenzo JA. Interleukin-7 influences osteoclast function in vivo but is not a critical factor in ovariectomy-induced bone loss. J Bone Miner Res. 2006 May;21(5):695-702.

Kacena MA, Nelson T, Clough ME, Lee SK, Lorenzo JA, Gundberg CM, HorowitzMC. Megakaryocyte-mediated inhibition of osteoclast development. Bone. 2006 39:991-999

Lee SK, Kadono Y, Okada F, Jacquin C, Koczon-Jaremko B, Gronowicz G, Adams DJ, Aguila HL, Choi Y, Lorenzo JA. T Lymphocyte Deficient Mice Lose Trabecular Bone Mass With Ovariectomy. J Bone Miner Res. 2006 Nov;21(11):1704-1712

Lee SH, Rho J, Jeong D, Sul JY, Kim T, Kim N, Kang JS, Miyamoto T, Suda T, Lee SK, Pignolo RJ, Koczon-Jaremko B, Lorenzo J, Choi Y. v-ATPase V(0) subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation. Nat Med. 2006 Dec. 12(12):1403-1409