Carl Malchoff, M.D., Ph.D.

Faculty Title: 
Professor of Medicine

Office Location:
Diabetes - Dowling South 860-679-3245
Endocrine Neoplasia - Cancer Center 860-679-2100

Specialties: 
Diabetes and Endocrine Neoplasia (thyroid cancer, thyroid nodules, pituitary tumors, Cushing's syndrome, adrenal tumors, hyperparathyroidism), but not osteoporosis

Board Certifications:
American Board of Internal Medicine
American Board of Internal Medicine - Endocrinology and Metabolism

Brief Biosketch: 
My major clinical interests are in endocrine neoplasia and diabetes mellitus.  I am director of the Endocrine Neoplasia program that integrates the skills of Endocrinology, Surgery, Urology, Neurosurgery, Invasive Radiology, and Neuroophthalmology in the care of patients with benign and malignant neoplasms of the thyroid, pituitary, parathyroid, and adrenal neoplasms.  I am directly involved in the following procedures: thyroid nodule aspiration, thyroid ultrasound, adrenal vein sampling (aldosteronism), and petrosal sinus sampling (Cushing's syndrome).  In diabetes I am director of the Diabetes Education Program at UCHC.  In addition to running clinical program that provides very high quality care, our goals are to educate the primary care physician to provide care for diabetic patients and to participate in clinical trials.
Research interests are primarily understanding the molecular basis of endocrine disorders.  Expertise includes adrenal disorders, glucocorticoid resistance, and familial papillary thyroid carcinoma.

Selected Publications
Reviews

C.D. Malchoff and D. M. Malchoff, “Glucocorticoid Resistance and Hypersensitivity,” in Endocrinol Metab Clin N Am, J. Findling, Editor, Elsevier  Saunders, 34: 315-326, 2005. 

C. D. Malchoff and D. M. Malchoff, “Familial Papillary Thyroid Carcinoma,” in  Progress in Thyroid Cancer Research, NOVA, in press, 2005. 

D.M. Malchoff and C.D. Malchoff, "Generalized Glucocorticoid Resistance," in  Endocrinology, 5th Edition, L.J.  DeGroot and J. Jameson, Editors, Elsevier Saunders, 2387-2392, 2006.  

C.D. Malchoff and D. M. Malchoff, “Familial Nonmedullary Thyroid Carcinoma,” Cancer Control: Journal of the Moffitt Cancer Center, in press, 2006.  

C.D. Malchoff and D.M. Malchoff, “Clinical syndromes of Glucocorticoid Sensitivity and Resistance.  Current Opinion in Endocrinology and Diabetes, 13:242-7, 2006.

Articles

F.M. Swords, A. Baig, D.M. Malchoff, C.D. Malchoff, M.O Thorner, P.J. King, L. Hunyady, and A.J.L. Clark, Impaired Desensitization of a Mutant Adrenocorticotropin Receptor Associated with Apparent Constitutive Activity, J Mol Endocrinol, 16: 2746-2753, 2002.

N. Sidoroupolis, C.D. Malchoff, J. Vento, and G. Whalen, Radioguided Tumorectomy: A Useful Tool in the Management of Parathyroid Adenomas, Archives of Surgery, 138: 716-20, 2003.

M.U. Nasir Khan, C.D. Malchoff, R. Weiner, P. Hegde, and R. Kozol, Intraopertive use of gamma probe for localization of recurrent gastrinoma, Contemporary Surgery, 60:371, 2004.

J. Wagner, C. D. Malchoff, and G. Abbott, Invasiveness as a Barrier to Self-Monitoring of Blood Glucose in Diabetes, Diabetes Technology and Therapeutics, 7:612-619, 2005.

L. Groussin, A. Horvath, E Jullian, S. Boikos, F. Rene-Corail, H. Lefebvre, F.-L. Cephise-Velayoudom, M.-C. Vantyghem, P. Chanson, B. Conte-Devolx, M. Lucas, A. Gentil, C. D. Malchoff, X. Bertagna, C.A. Stratakis, and J. Bertherat, A mutation of the regulatory subunit R1 of PKA gene (PRKAR1A) is responsible only for primary pigmented nodular adrenocortical disease (PPNAD) in 12 kindreds; the first evidence for a PRKAR1A-genotype-specific phenotype, J Clin Endocrinol and Metabolism, 91: 1943-1949, 2006.